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Non sedating anti histamine

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Histamines encourage the body to rid itself of the allergen by triggering ways to flush the allergen, such as watery eyes, a runny nose and sneezing; if the skin is the affected area, the histamines may produce a rash as protection.

Antihistamines block histamines, thereby preventing some or all of the allergen's effects, but early antihistamines often caused drowsiness.

This sedating activity is sometimes used in managing conditions such as eczema where sleep maybe disturbed due to pruritus.

They will also reduce histamineinduced secretions, including excessive tears and salivation.

In patients with urticaria resistant to the standard dosage of cetirizine or fexofenadine, doubling the daily dose may be effective.

In a study of 51 patients treated with cetirizine at a dosage of 10 mg once daily, 18 patients had an inadequate response and were randomized to further treatment with either cetirizine 20 mg once daily or olopatadine 5 mg twice daily.

Chronic urticaria may benefit from doxepin, a tricyclic antidepressant with potent antihistamine properties.

Because of its significant sedative properties, it should be given at bedtime.